By 2040, the future of work and health will be shaped by rapid transformations across technology, climate, the economy, politics and society. This evolving landscape will present both urgent challenges and critical opportunities for practitioners and policy-makers promoting the health, safety and wellbeing of the working population. This report applies strategic foresight methods to explore a wide range of plausible futures and their potential implications for workplaces and their workers. It helps to anticipate what’s coming, question assumptions and build more adaptive, equitable and resilient approaches to promoting worker health, safety and wellbeing.